Involvement of the Spinal Cord in the Alzheimer’s Disease: A Literature Review

AUTHORS

Francesco Raudino 1 , *

AUTHORS INFORMATION

1 Department of Neurology, Valduce Hospital, Como, Italy

ARTICLE INFORMATION

Archives of Neuroscience: 3 (4); e93452
Published Online: August 08, 2016
Article Type: Review Article
Received: May 12, 2019
Accepted: June 06, 2016
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Abstract

Context: Pathologic studies often show an involvement of the spinal cord in the early stages of the Alzheimer’s (AD) disease; clinical studies further show a statistically-relevant frequency of gait impairment and an increased risk of falling. Therefore, the spinal cord is possibly involved in the Alzheimer’s disease and has a role in the appearance of some symptoms.

Evidence Acquisition: Medline literature search.

Results: Several pathologic studies in animals and humans show abnormalities in the spinal cord and particularly in the anterior horn lesions that are typical of AD. Several clinical studies show frequent and precocious impairment of the gait, which is possibly related to the pathology of the spinal cord.

Conclusions: The AD disease does not only affect the brain, and cognitive symptoms, as well as non-cognitive symptoms are typical of the early stages of the disease.

Keywords

Alzheimer’s Disease Spinal Cord in Alzheimer’s Disease Non-Cognitive Symptoms in Alzheimer’s Disease

© 2016, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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