Cell Therapy in Parkinson’s Disease

AUTHORS

Rafieh Alizadeh 1 , Soraya Mehrabi 2 , Mahmoudreza Hadjighassem 2 , 3 , *

AUTHORS INFORMATION

1 Department of Anatomy, Tehran University of Medical Sciences, Tehran, IR Iran

2 Department of Neuroscience, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, IR Iran

3 Brain and Spinal cord Injury Research Center, Tehran University of Medical Sciences, Tehran, IR Iran

ARTICLE INFORMATION

Archives of Neuroscience: 1 (2); e93441
Published Online: July 01, 2014
Article Type: Review Article
Received: May 12, 2019
Accepted: September 30, 2013

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Abstract

Context: Parkinson's disease (PD) is one of the common neurodegenerative disorders, characterized by the gradual loss of dopamine (DA) containing neurons in the substantia nigra. It is currently treated by L-DOPA and DAergic drugs. Although these treatments are very effective in the beginning of the disease, but they are not curative and have side effects in chronic use.

Evidence Acquisitions: The aim of cell replacement therapies for PD is looking for a long-lasting relief of patients’ symptoms. Different sources of stem cells are recruited to establish a long lasting treatment for PD. We have categorized them into embryonic stem cells from the fertilized egg, neural stem cells from the embryonic or adult brain, mesenchymal stem cell, and stem cells from other tissues. In this review we used three key words "Parkinson's disease, stem cells and neostriatum transplantation" to search in "PubMed" search engine. We found more than hundreds of publications but limitation for citation led us to select only those that were more innovative.

Results: Cell replacement therapies in PD aim to provide greater long-lasting relief of patients’ symptoms. Although the transplants survive, reinnervate the striatum, and generate adequate symptomatic relief in some patients yet side effects are still major concern.

Conclusions: This article reviewed different sources of cell used in transplantation and focused on their advantages and disadvantages in transplantation studies.

Keywords

Parkinson Disease Stem Cells Neostriatum Transplantation Dopaminergic Neurons

© 2014, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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