Archives of Neuroscience

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Multitarget Effects of Coconut Oil (Virgin Type) on Aβ-Induced Alzheimer’s Disease Animal Model

Fatemeh Mirzaei 1 , Mozafar Khazaei 2 , Alireza Komaki 3 , Iraj Amiri 4 and Cyrus Jalili 2 , *
Authors Information
1 Department of Anatomy and Cell Biology, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
4 Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Article information
  • Archives of Neuroscience: 6 (2); e85715
  • Published Online: April 14, 2019
  • Article Type: Research Article
  • Received: October 24, 2018
  • Revised: December 2, 2018
  • Accepted: December 12, 2018
  • DOI: 10.5812/ans.85715

To Cite: Mirzaei F, Khazaei M, Komaki A, Amiri I, Jalili C. Multitarget Effects of Coconut Oil (Virgin Type) on Aβ-Induced Alzheimer’s Disease Animal Model, Arch Neurosci. Online ahead of Print ; 6(2):e85715. doi: 10.5812/ans.85715.

Copyright © 2019, Archives of Neuroscience. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Kocahan S, Dogan Z. Mechanisms of Alzheimer's disease pathogenesis and prevention: The brain, neural pathology, n-methyl-d-aspartate receptors, tau protein and other risk factors. Clin Psychopharmacol Neurosci. 2017;15(1):1-8. doi: 10.9758/cpn.2017.15.1.1. [PubMed: 28138104]. [PubMed Central: PMC5290713].
  • 2. Butterfield DA, Boyd-Kimball D. Oxidative stress, amyloid-beta peptide, and altered key molecular pathways in the pathogenesis and progression of alzheimer's disease. J Alzheimers Dis. 2018;62(3):1345-67. doi: 10.3233/JAD-170543. [PubMed: 29562527]. [PubMed Central: PMC5870019].
  • 3. Randino R, Grimaldi M, Persico M, De Santis A, Cini E, Cabri W, et al. Investigating the neuroprotective effects of turmeric extract: Structural interactions of beta-amyloid peptide with single curcuminoids. Sci Rep. 2016;6:38846. doi: 10.1038/srep38846. [PubMed: 28004737]. [PubMed Central: PMC5177957].
  • 4. Vysakh A, Ratheesh M, Rajmohanan TP, Pramod C, Premlal S, Girish kumar B, et al. Polyphenolics isolated from virgin coconut oil inhibits adjuvant induced arthritis in rats through antioxidant and anti-inflammatory action. Int Immunopharmacol. 2014;20(1):124-30. doi: 10.1016/j.intimp.2014.02.026. [PubMed: 24613207].
  • 5. Abujazia MA, Muhammad N, Shuid AN, Soelaiman IN. The effects of virgin coconut oil on bone oxidative status in ovariectomised rat. Evid Based Complement Alternat Med. 2012;2012:525079. doi: 10.1155/2012/525079. [PubMed: 22927879]. [PubMed Central: PMC3426286].
  • 6. Handayani R, Sulistyo J, Rahayu RD. Extraction of coconut oil (Cocos nucifera L.) through fermentation system. Biodiversitas J Biol Divers. 2009;10(3). doi: 10.13057/biodiv/d100309.
  • 7. Oshaghi EA, Khodadadi I, Tavilani H, Goodarzi MT. Aqueous extract of anethum graveolens L. has potential antioxidant and antiglycation effects. Iran J Med Sci. 2016;41(4):328-33. [PubMed: 27365555]. [PubMed Central: PMC4912652].
  • 8. Mirzaei F, Khazaei M, Komaki A, Amiri I, Jalili C. Virgin coconut oil (VCO) by normalizing NLRP3 inflammasome showed potential neuroprotective effects in Amyloid-beta induced toxicity and high-fat diet fed rat. Food Chem Toxicol. 2018;118:68-83. doi: 10.1016/j.fct.2018.04.064. [PubMed: 29729307].
  • 9. Soodi M, Naghdi N, Hajimehdipoor H, Choopani S, Sahraei E. Memory-improving activity of Melissa officinalis extract in naive and scopolamine-treated rats. Res Pharm Sci. 2014;9(2):107-14. [PubMed: 25657779]. [PubMed Central: PMC4311288].
  • 10. Abbasi-Oshaghi E, Mirzaei F, Mirzaei A. Effects of ZnO nanoparticles on intestinal function and structure in normal/high fat diet-fed rats and Caco-2 cells. Nanomedicine (Lond). 2018;13(21):2791-816. doi: 10.2217/nnm-2018-0202. [PubMed: 30394178].
  • 11. Mohammadi A, Mirzaei F, Jamshidi M, Yari R, Pak S, Norouzian P, et al. Influence of flaxseed on lipid profiles and expression of LXRa, in intestine of diabetic rat. Int J Biol. 2013;5(4). doi: 10.5539/ijb.v5n4p23.
  • 12. Li R, Yang L, Lindholm K, Konishi Y, Yue X, Hampel H, et al. Tumor necrosis factor death receptor signaling cascade is required for amyloid-beta protein-induced neuron death. J Neurosci. 2004;24(7):1760-71. doi: 10.1523/JNEUROSCI.4580-03.2004. [PubMed: 14973251].
  • 13. Swardfager W, Lanctot K, Rothenburg L, Wong A, Cappell J, Herrmann N. A meta-analysis of cytokines in Alzheimer's disease. Biol Psychiatry. 2010;68(10):930-41. doi: 10.1016/j.biopsych.2010.06.012. [PubMed: 20692646].
  • 14. Qiao X, Cummins DJ, Paul SM. Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse. Eur J Neurosci. 2001;14(3):474-82. doi: 10.1046/j.0953-816x.2001.01666.x. [PubMed: 11553297].
  • 15. Arimon M, Takeda S, Post KL, Svirsky S, Hyman BT, Berezovska O. Oxidative stress and lipid peroxidation are upstream of amyloid pathology. Neurobiol Dis. 2015;84:109-19. doi: 10.1016/j.nbd.2015.06.013. [PubMed: 26102023]. [PubMed Central: PMC4684986].
  • 16. Abbasi Oshaghi E, Goodarzi MT, Higgins V, Adeli K. Role of resveratrol in the management of insulin resistance and related conditions: Mechanism of action. Crit Rev Clin Lab Sci. 2017;54(4):267-93. doi: 10.1080/10408363.2017.1343274. [PubMed: 28704113].
  • 17. Farajdokht F, Amani M, Mirzaei Bavil F, Alihemmati A, Mohaddes G, Babri S. Troxerutin protects hippocampal neurons against amyloid beta-induced oxidative stress and apoptosis. EXCLI J. 2017;16:1081-9. doi: 10.17179/excli2017-526. [PubMed: 29285004]. [PubMed Central: PMC5735350].
  • 18. Goodarzi MT, Khodadadi I, Tavilani H, Abbasi Oshaghi E. The role of anethum graveolens L. (Dill) in the management of diabetes. J Trop Med. 2016;2016:1098916. doi: 10.1155/2016/1098916. [PubMed: 27829842]. [PubMed Central: PMC5088306].
  • 19. Papandreou MA, Tsachaki M, Efthimiopoulos S, Cordopatis P, Lamari FN, Margarity M. Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection. Behav Brain Res. 2011;219(2):197-204. doi: 10.1016/j.bbr.2011.01.007. [PubMed: 21238492].
  • 20. Tran MH, Yamada K, Olariu A, Mizuno M, Ren XH, Nabeshima T. Amyloid beta-peptide induces nitric oxide production in rat hippocampus: Association with cholinergic dysfunction and amelioration by inducible nitric oxide synthase inhibitors. FASEB J. 2001;15(8):1407-9. doi: 10.1096/fj.00-0719fje. [PubMed: 11387239].
  • 21. Liu H, Chen JP, Zhang WQ. [Inducible nitric oxide synthase induces beta-amyloid neurotoxicity in vivo]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2002;18(4):329-32. Chinese. [PubMed: 21174802].

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