Archives of Neuroscience

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Evaluation of the Relationship Between Serum Sodium Concentration and Mortality Rate in ICU Patients with Traumatic Brain Injury

Babak Ali Kiaei 1 , Darioush Moradi Farsani 1 , * , Keyvan Ghadimi 2 and Mahnaz Shahali 2
Authors Information
1 Assistant Professor, Department of Anesthesiology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran
2 School of Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran
Article information
  • Archives of Neuroscience: July 2018, 5 (3); e67845
  • Published Online: July 3, 2018
  • Article Type: Research Article
  • Received: February 23, 2018
  • Revised: April 13, 2018
  • Accepted: May 9, 2018
  • DOI: 10.5812/ans.67845

To Cite: Ali Kiaei B, Moradi Farsani D, Ghadimi K, Shahali M. Evaluation of the Relationship Between Serum Sodium Concentration and Mortality Rate in ICU Patients with Traumatic Brain Injury, Arch Neurosci. 2018 ; 5(3):e67845. doi: 10.5812/ans.67845.

Copyright © 2018, Archives of Neuroscience. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Robertson GL. Diabetes insipidus. Endocrinol Metab Clin North Am. 1995;24(3):549-72. [PubMed: 8575409].
  • 2. Doczi T, Bende J, Huszka E, Kiss J. Syndrome of inappropriate secretion of antidiuretic hormone after subarachnoid hemorrhage. Neurosurgery. 1981;9(4):394-7. [PubMed: 7301084].
  • 3. Bradshaw K, Smith M. Disorders of sodium balance after brain injury. Cont Educ In Anaesth Crit Care Pa. 2008;8(4):129-33. doi: 10.1093/bjaceaccp/mkn019.
  • 4. Gabbe BJ, Lyons RA, Lecky FE, Bouamra O, Woodford M, Coats TJ, et al. Comparison of mortality following hospitalisation for isolated head injury in England and Wales, and Victoria, Australia. PLoS One. 2011;6(5). e20545. doi: 10.1371/journal.pone.0020545. [PubMed: 21655237]. [PubMed Central: PMC3105093].
  • 5. Levi M, van der Poll T, ten Cate H, van Deventer SJ. The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia. Eur J Clin Invest. 1997;27(1):3-9. [PubMed: 9041370].
  • 6. Maggiore U, Picetti E, Antonucci E, Parenti E, Regolisti G, Mergoni M, et al. The relation between the incidence of hypernatremia and mortality in patients with severe traumatic brain injury. Crit Care. 2009;13(4):R110. doi: 10.1186/cc7953. [PubMed: 19583864]. [PubMed Central: PMC2750153].
  • 7. Lisman T, Leuvenink HG, Porte RJ, Ploeg RJ. Activation of hemostasis in brain dead organ donors: an observational study. J Thromb Haemost. 2011;9(10):1959-65. doi: 10.1111/j.1538-7836.2011.04442.x. [PubMed: 21762465].
  • 8. Barklin A. Systemic inflammation in the brain-dead organ donor. Acta Anaesthesiol Scand. 2009;53(4):425-35. doi: 10.1111/j.1399-6576.2008.01879.x. [PubMed: 19226294].
  • 9. Belzberg H, Shoemaker WC, Wo CC, Nicholls TP, Dang AB, Zelman V, et al. Hemodynamic and oxygen transport patterns after head trauma and brain death: implications for management of the organ donor. J Trauma. 2007;63(5):1032-42. doi: 10.1097/01.ta.0000235995.86162.d2. [PubMed: 17993948].
  • 10. Amini S, Heydari Z. [Sodium disturbances and its relation with mortality and morbidity in head trauma patients admitted to general ICU at Zahedan Khatam-Al-Anbia Hospital from May 2003 to September 2004]. J Iranian Soc Anaesthesiol And Intens Care. 2007;29(57):24-30. Persian.
  • 11. Waikar SS, Mount DB, Curhan GC. Mortality after hospitalization with mild, moderate, and severe hyponatremia. Am J Med. 2009;122(9):857-65. doi: 10.1016/j.amjmed.2009.01.027. [PubMed: 19699382]. [PubMed Central: PMC3033702].
  • 12. Mokhtari M, Goharani R, Miri M, Eghtesadi Araghi P. [Frequency of Hyper-and Hypo-natremia in Patients admitted in the ICU and comparison of their association with mortality]. Res Med. 2010;33(3):183-8. Persian.
  • 13. Palevsky PM. Hypernatremia. Semin Nephrol. 1998;18(1):20-30. [PubMed: 9459286].
  • 14. Polderman KH, Schreuder WO, Strack van Schijndel RJ, Thijs LG. Hypernatremia in the intensive care unit: an indicator of quality of care? Crit Care Med. 1999;27(6):1105-8. [PubMed: 10397213].
  • 15. Aiyagari V, Deibert E, Diringer MN. Hypernatremia in the neurologic intensive care unit: how high is too high? J Crit Care. 2006;21(2):163-72. doi: 10.1016/j.jcrc.2005.10.002. [PubMed: 16769461].
  • 16. Lindner G, Funk GC, Schwarz C, Kneidinger N, Kaider A, Schneeweiss B, et al. Hypernatremia in the critically ill is an independent risk factor for mortality. Am J Kidney Dis. 2007;50(6):952-7. doi: 10.1053/j.ajkd.2007.08.016. [PubMed: 18037096].
  • 17. Hoorn EJ, Zietse R. Hyponatremia and mortality: moving beyond associations. Am J Kidney Dis. 2013;62(1):139-49. doi: 10.1053/j.ajkd.2012.09.019. [PubMed: 23291150].

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