Archives of Neuroscience

Published by: Kowsar

Scaffolds for Intracerebral Grafting of Neural Progenitor Cells After Cerebral Infarction: A Systematic Review

Laura K Cohen 1 and Matthew B Jensen 2 , *
Authors Information
1 Johns Hopkins University, School of Medicine, Baltimore, USA
2 Department of Neurology, University of Wisconsin, Madison, USA
Article information
  • Archives of Neuroscience: October 01, 2015, 2 (4); e25364
  • Published Online: October 24, 2015
  • Article Type: Review Article
  • Received: November 22, 2014
  • Revised: December 29, 2014
  • Accepted: January 10, 2015
  • DOI: 10.5812/archneurosci.25364

To Cite: Cohen L K, Jensen M B. Scaffolds for Intracerebral Grafting of Neural Progenitor Cells After Cerebral Infarction: A Systematic Review, Arch Neurosci. 2015 ; 2(4):e25364. doi: 10.5812/archneurosci.25364.

Copyright © 2015, Tehran University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Benowitz LI, Carmichael ST. Promoting axonal rewiring to improve outcome after stroke. Neurobiol Dis. 2010; 37(2): 259-66[DOI][PubMed]
  • 2. Gilman S. Time course and outcome of recovery from stroke: relevance to stem cell treatment. Exp Neurol. 2006; 199(1): 37-41[DOI][PubMed]
  • 3. Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, et al. Heart disease and stroke statistics--2011 update: a report from the American Heart Association. Circulation. 2011; 123(4)[DOI][PubMed]
  • 4. Bliss TM, Andres RH, Steinberg GK. Optimizing the success of cell transplantation therapy for stroke. Neurobiol Dis. 2010; 37(2): 275-83[DOI][PubMed]
  • 5. Delcroix GJ, Schiller PC, Benoit JP, Montero-Menei CN. Adult cell therapy for brain neuronal damages and the role of tissue engineering. Biomaterials. 2010; 31(8): 2105-20[DOI][PubMed]
  • 6. Potter W, Kalil RE, Kao WJ. Biomimetic material systems for neural progenitor cell-based therapy. Front Biosci. 2008; 13: 806-21[PubMed]
  • 7. Park KI, Teng YD, Snyder EY. The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue. Nat Biotechnol. 2002; 20(11): 1111-7[DOI][PubMed]
  • 8. Bible E, Chau DY, Alexander MR, Price J, Shakesheff KM, Modo M. The support of neural stem cells transplanted into stroke-induced brain cavities by PLGA particles. Biomaterials. 2009; 30(16): 2985-94[DOI][PubMed]
  • 9. Yu H, Cao B, Feng M, Zhou Q, Sun X, Wu S, et al. Combinated transplantation of neural stem cells and collagen type I promote functional recovery after cerebral ischemia in rats. Anat Rec (Hoboken). 2010; 293(5): 911-7[DOI][PubMed]
  • 10. Jin K, Mao X, Xie L, Galvan V, Lai B, Wang Y, et al. Transplantation of human neural precursor cells in Matrigel scaffolding improves outcome from focal cerebral ischemia after delayed postischemic treatment in rats. J Cereb Blood Flow Metab. 2010; 30(3): 534-44[DOI][PubMed]
  • 11. Zhong J, Chan A, Morad L, Kornblum HI, Fan G, Carmichael ST. Hydrogel matrix to support stem cell survival after brain transplantation in stroke. Neurorehabil Neural Repair. 2010; 24(7): 636-44[DOI][PubMed]
  • 12. Jin K, Mao X, Xie L, Greenberg RB, Peng B, Moore A, et al. Delayed transplantation of human neural precursor cells improves outcome from focal cerebral ischemia in aged rats. Aging Cell. 2010; 9(6): 1076-83[DOI][PubMed]
  • 13. Bible E, Dell'Acqua F, Solanky B, Balducci A, Crapo PM, Badylak SF, et al. Non-invasive imaging of transplanted human neural stem cells and ECM scaffold remodeling in the stroke-damaged rat brain by (19)F- and diffusion-MRI. Biomaterials. 2012; 33(10): 2858-71[DOI][PubMed]
  • 14. Bible E, Qutachi O, Chau DY, Alexander MR, Shakesheff KM, Modo M. Neo-vascularization of the stroke cavity by implantation of human neural stem cells on VEGF-releasing PLGA microparticles. Biomaterials. 2012; 33(30): 7435-46[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .
Readers' Comments