Archives of Neuroscience

Published by: Kowsar

Etomidate: A Complementary Diagnostic Tool for Pre-Surgical Evaluation in Temporal Lobe Epilepsy

Lorena Vega-Zelaya 1 , Ancor Sanz-Garcia 2 , Guillermo J Ortega 2 , Rafael G de Sola 3 and Jesus Pastor 1 , *
Authors Information
1 Clinical Neurophysiology Research Foundation, Hospital Universitario De La Princesa, Madrid, Spain
2 Research Foundation, Hospital Universitario De La Princesa, Madrid, Spain
3 Neurosurgery, Research Foundation, Hospital Universitario De La Princesa, Madrid, Spain
Article information
  • Archives of Neuroscience: October 01, 2016, 3 (4); e34915
  • Published Online: March 12, 2016
  • Article Type: Review Article
  • Received: November 29, 2015
  • Revised: January 27, 2016
  • Accepted: February 6, 2016
  • DOI: 10.5812/archneurosci.34915

To Cite: Vega-Zelaya L, Sanz-Garcia A, Ortega G J, de Sola R G, Pastor J. Etomidate: A Complementary Diagnostic Tool for Pre-Surgical Evaluation in Temporal Lobe Epilepsy, Arch Neurosci. 2016 ; 3(4):e34915. doi: 10.5812/archneurosci.34915.

Copyright © 2016, Tehran University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Blair RD. Temporal lobe epilepsy semiology. Epilepsy Res Treat. 2012; 2012: 1-10[DOI][PubMed]
  • 2. Sola RG, Hernando-Requejo V, Pastor J, Garcia-Navarrete E, DeFelipe J, Alijarde MT, et al. Pharmacoresistant temporal-lobe epilepsy. Exploration with foramen ovale electrodes and surgical outcomes. Rev Neurol. 2005; 41(1): 4-16
  • 3. Luders HO, Awad I. Epilepsy surgery. 1991; : 51-6
  • 4. Pastor J, Hernando-Requejo V, Dominguez-Gadea L, de Llano I, Meilan-Paz ML, Martinez-Chacon JL, et al. Impact of experience on improving the surgical outcome in temporal lobe epilepsy. Rev Neurol. 2005; 41(12): 709-16[PubMed]
  • 5. Diehl B, Luders HO. Temporal lobe epilepsy: when are invasive recordings needed? Epilepsia. 2000; 41 Suppl 3-74[PubMed]
  • 6. Brockhaus A, Lehnertz K, Wienbruch C, Kowalik A, Burr W, Elbert T, et al. Possibilities and limitations of magnetic source imaging of methohexital-induced epileptiform patterns in temporal lobe epilepsy patients. Electroencephalogr Clin Neurophysiol. 1997; 102(5): 423-36[PubMed]
  • 7. Schmitt H, Druschky K, Hummel C, Stefan H. Detection of an epileptic mirror focus after oral application of clonidine. Br J Anaesth. 1999; 83(2): 349-51[PubMed]
  • 8. Barba C, Di Giuda D, Policicchio D, Bruno I, Papacci F, Colicchio G. Correlation between provoked ictal SPECT and depth recordings in adult drug-resistant epilepsy patients. Epilepsia. 2007; 48(2): 278-85[DOI][PubMed]
  • 9. Kofke WA, Dasheiff RM, Dong ML, Whitehurst S, Caldwell M. Anesthetic care during thiopental tests to evaluate epileptic patients for surgical therapy. J Neurosurg Anesthesiol. 1993; 5(3): 164-70[PubMed]
  • 10. Manninen PH, Burke SJ, Wennberg R, Lozano AM, El Beheiry H. Intraoperative localization of an epileptogenic focus with alfentanil and fentanyl. Anesth Analg. 1999; 88(5): 1101-6[PubMed]
  • 11. Krieger W, Copperman J, Laxer KD. Seizures with etomidate anesthesia. Anesth Analg. 1985; 64(12): 1226-7[PubMed]
  • 12. Ebrahim ZY, DeBoer GE, Luders H, Hahn JF, Lesser RP. Effect of etomidate on the electroencephalogram of patients with epilepsy. Anesth Analg. 1986; 65(10): 1004-6[PubMed]
  • 13. Gancher S, Laxer KD, Krieger W. Activation of epileptogenic activity by etomidate. Anesthesiology. 1984; 61(5): 616-8[PubMed]
  • 14. Pastor J, Wix R, Meilan ML, Martinez-Chacon JL, de Dios E, Dominguez-Gadea L, et al. Etomidate accurately localizes the epileptic area in patients with temporal lobe epilepsy. Epilepsia. 2010; 51(4): 602-9[DOI][PubMed]
  • 15. Stefan H, Heers M, Schmitt HJ, Rauch C, Kaltenhauser M, Rampp S. Increased spike frequency during general anesthesia with etomidate for magnetoencephalography in patients with focal epilepsies. Clin Neurophysiol. 2010; 121(8): 1220-6[DOI][PubMed]
  • 16. Rampp S, Schmitt HJ, Heers M, Schonherr M, Schmitt FC, Hopfengartner R, et al. Etomidate activates epileptic high frequency oscillations. Clin Neurophysiol. 2014; 125(2): 223-30[DOI][PubMed]
  • 17. Vega-Zelaya L, Pastor J, Tormo I, de Sola RG, Ortega GJ. Assessing the equivalence between etomidate and seizure network dynamics in temporal lobe epilepsy. Clin Neurophysiol. 2016; 127(1): 169-78[DOI][PubMed]
  • 18. Doenicke A, Loffler B, Kugler J, Suttmann H, Grote B. Plasma concentration and E.E.G. after various regimens of etomidate. Br J Anaesth. 1982; 54(4): 393-400[PubMed]
  • 19. Arden JR, Holley FO, Stanski DR. Increased sensitivity to etomidate in the elderly: initial distribution versus altered brain response. Anesthesiology. 1986; 65(1): 19-27[PubMed]
  • 20. Voss LJ, Sleigh JW, Barnard JP, Kirsch HE. The howling cortex: seizures and general anesthetic drugs. Anesth Analg. 2008; 107(5): 1689-703[DOI][PubMed]
  • 21. Rath M, Fohr KJ, Weigt HU, Gauss A, Engele J, Georgieff M, et al. Etomidate reduces glutamate uptake in rat cultured glial cells: involvement of PKA. Br J Pharmacol. 2008; 155(6): 925-33[DOI][PubMed]
  • 22. Cohen I, Navarro V, Clemenceau S, Baulac M, Miles R. On the origin of interictal activity in human temporal lobe epilepsy in vitro. Science. 2002; 298(5597): 1418-21[DOI][PubMed]
  • 23. Herrera-Peco I, Ortega GJ, Hernando-Requejo V, Sola RG, Pastor J. Voltage sources in mesial temporal area induced by etomidate. Rev Neurol. 2010; 51(5): 263-70[PubMed]
  • 24. Vega-Zelaya L, Garnés-Camarena O, Ortega GJ, de Sola RG, Pastor J. New Advances in the Understanding of the Current Sources of Epileptic Activity in Mesial Areas.
  • 25. Pastor J, de la Prida LM, Hernando V, Sola RG. Voltage sources in mesial temporal lobe epilepsy recorded with foramen ovale electrodes. Clin Neurophysiol. 2006; 117(12): 2604-14[DOI][PubMed]
  • 26. Malmivuo J, Plonsey R. Bioelectromagnetism: principles and applications of bioelectric and biomagnetic fields. 1995;
  • 27. Ponten SC, Bartolomei F, Stam CJ. Small-world networks and epilepsy: graph theoretical analysis of intracerebrally recorded mesial temporal lobe seizures. Clin Neurophysiol. 2007; 118(4): 918-27[DOI][PubMed]
  • 28. Schindler KA, Bialonski S, Horstmann MT, Elger CE, Lehnertz K. Evolving functional network properties and synchronizability during human epileptic seizures. Chaos. 2008; 18(3): 33119[DOI][PubMed]
  • 29. Rezek IA, Roberts SJ. Stochastic complexity measures for physiological signal analysis. IEEE Trans Biomed Eng. 1998; 45(9): 1186-91[DOI][PubMed]
  • 30. Bettus G, Guedj E, Joyeux F, Confort-Gouny S, Soulier E, Laguitton V, et al. Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms. Hum Brain Mapp. 2009; 30(5): 1580-91[DOI][PubMed]
  • 31. Pereira FR, Alessio A, Sercheli MS, Pedro T, Bilevicius E, Rondina JM, et al. Asymmetrical hippocampal connectivity in mesial temporal lobe epilepsy: evidence from resting state fMRI. BMC Neurosci. 2010; 11: 66[DOI][PubMed]
  • 32. Ortega GJ, Peco IH, Sola RG, Pastor J. Impaired mesial synchronization in temporal lobe epilepsy. Clin Neurophysiol. 2011; 122(6): 1106-16[DOI][PubMed]
  • 33. Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010; 51(4): 676-85[DOI][PubMed]
  • 34. Terry JR, Benjamin O, Richardson MP. Seizure generation: the role of nodes and networks. Epilepsia. 2012; 53(9): 166-9[DOI][PubMed]
  • 35. Gooding JM, Weng JT, Smith RA, Berninger GT, Kirby RR. Cardiovascular and pulmonary responses following etomidate induction of anesthesia in patients with demonstrated cardiac disease. Anesth Analg. 1979; 58(1): 40-1[PubMed]
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