Archives of Neuroscience

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Evidence-Based Pharmacotherapy of Epilepsy

Zahra Tolou Ghamari 1 , * , Jafar Mehavari Habibabadi 2 and Abbas Ali Palizban 3
Authors Information
1 Isfahan Neurosciences Research Centre, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran
2 Department of Neurology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran
3 Department of Clinical Biochemistry, Isfahan University of Medical Sciences, Isfahan, IR Iran
Article information
  • Archives of Neuroscience: January 01, 2015, 2 (1); e18468
  • Published Online: January 1, 2015
  • Article Type: Research Article
  • Received: February 24, 2014
  • Revised: March 2, 2014
  • Accepted: March 10, 2014
  • DOI: 10.5812/archneurosci.18468

To Cite: Tolou Ghamari Z, Mehavari Habibabadi J, Palizban A A. Evidence-Based Pharmacotherapy of Epilepsy, Arch Neurosci. 2015 ; 2(1):e18468. doi: 10.5812/archneurosci.18468.

Abstract
Copyright © 2015, Tehran University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Chandra S, Kurwale N, Tripathi M, Banerjee J. Epileptogenic networks and drug-resistant epilepsy: Present and future perspectives of epilepsy research-Utility for the epileptologist and the epilepsy surgeon. Ann Indian Acad Neur. 2014; 17(5): 134[DOI]
  • 2. Kalviainen R, Ansakorpi H, Flander S, Immonen A, Keranen T, Kivisto J, et al. [Update on Current Care Guideline: epilepsies (adult]. Duodecim. 2014; 130(7): 748-9[PubMed]
  • 3. Franchi C, Giussani G, Messina P, Montesano M, Romi S, Nobili A. Validation of healthcare administrative data for the diagnosis of epilepsy. J Epidemiol Community Health. 2013; 67(12)[DOI]
  • 4. Wiebe S. Definition of drug-resistant epilepsy: Is it evidence based? Epilepsia. 2013; 54: 9-12[DOI]
  • 5. Weaver DF, Pohlmann-Eden B. Pharmacoresistant epilepsy: Unmet needs in solving the puzzle(s). Epilepsia. 2013; 54: 80-5[DOI]
  • 6. Hao X, Goldberg D, Kelly K, Stephen L, Kwan P, Brodie MJ. Uncontrolled epilepsy is not necessarily the same as drug-resistant epilepsy: differences between populations with newly diagnosed epilepsy and chronic epilepsy. Epilepsy Behav. 2013; 29(1): 4-6[DOI][PubMed]
  • 7. Gregory JK, Broomall EM. Teaching Video NeuroImages: Reading epilepsy: A seizure in a thousand words (or less). Neurology. 2013; 81(13)[DOI]
  • 8. Cecen GS, Gulabi D, Oltulu I, Onay T. Generalized epileptic seizure in an adolescent idiopathic scoliosis (AIS) patient with syringomyelia after deformity correction surgery. Int J Surg Case Rep. 2013; 4(8): 740-3[DOI]
  • 9. Lasoń W, Chlebicka M, Rejdak K. Research advances in basic mechanisms of seizures and antiepileptic drug action. Pharmacol Rep. 2013; 65(4): 787-801[DOI]
  • 10. Tolou Ghamari Z. Antiepileptic Drugs (AEDs) Polypharmacy could lead to buried pharmacokinetic interactions due to CYP450. Drug Metab Lett . 2012; 6(3): 207-12
  • 11. Tolou-Ghamari Z, Najafi MR, Habibabadi JM, Zare M. Preliminarily Analysis of Carbamazepine (CBZ) C0 in Patients Visited Isfahan Epileptic Clinics. Int J Prev Med. 2013; 4-6[PubMed]
  • 12. Tolou-Ghamari Z, Zare M, Habibabadi JM, Najafi MR. Antiepileptic drugs: a consideration of clinical and biochemical outcome in patients with epilepsy. Int J Prev Med. 2013; 4-7[PubMed]
  • 13. Tolou-Ghamari Z, Zare M, Habibabadi JM, Najafi MR. A quick review of carbamazepine pharmacokinetics in epilepsy from 1953 to 2012. J Res Med Sci. 2013; 18-5[PubMed]
  • 14. French JA, Faught E. Rational polytherapy. Epilepsia. 2009; 50: 63-8[DOI]
  • 15. Guberman A. Monotherapy or polytherapy for epilepsy? . Can J Neurol Sci. 1998; 25(4)-8
  • 16. Arroyo S, Perucca E. Translating monotherapy trials into clinical practice: a look into the abyss. Epilepsy Behav. 2003; 4(5): 457-63[DOI]
  • 17. Glauser T, Ben-Menachem E, Bourgeois B, Cnaan A, Chadwick D, Guerreiro C, et al. ILAE Treatment Guidelines: Evidence-based Analysis of Antiepileptic Drug Efficacy and Effectiveness as Initial Monotherapy for Epileptic Seizures and Syndromes. Epilepsia. 2006; 47(7): 1094-120[DOI]
  • 18. Macdonald RL, Kelly KM. Antiepileptic Drug Mechanisms of Action. Epilepsia. 1995; 36[DOI]
  • 19. Shank RP, Gardocki JF, Streeter AJ, Maryanoff BE. An Overview of the Preclinical Aspects of Topiramate: Pharmacology, Pharmacokinetics, and Mechanism of Action. Epilepsia. 2000; 41: 3-9[DOI]
  • 20. Luszczki JJ, Czuczwar M, Kis J, Krysa J, Pasztelan I, Swiader M, et al. Interactions of lamotrigine with topiramate and first-generation antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis. Epilepsia. 2003; 44(8): 1003-13[PubMed]
  • 21. Contin M, Riva R, Albani F, Avoni P, Baruzzi A. Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs. Ther Drug Monit. 2002; 24(3): 332-7[PubMed]
  • 22. Jenner P, Pratt JA, Marsden CD. Mechanism of action of clonazepam in myoclonus in relation to effects on GABA and 5-HT. Adv Neurol. 1986; 43: 629-43[PubMed]
  • 23. Mallucci GR, Nowack A, Malarkey EB, Yao J, Bleckert A, Hill J, et al. Levetiracetam Reverses Synaptic Deficits Produced by Overexpression of SV2A. PLoS ONE. 2011; 6(12)[DOI]
  • 24. Sankar R. GABAA Receptor Physiology and Its Relationship to the Mechanism of Action of the 1,5-Benzodiazepine Clobazam. CNS Drugs. 2012; 26(3): 229-44[DOI]
  • 25. Tapalaga D, Suciu A, Schvartz M, Duca S. [The mechanism of action of phenobarbital on the metabolism of 131J-B.S.P. in cholestasis induced by ANIT in isolated and perfused rat liver (author's transl)]. Dtsch Z Verdau Stoffwechselkr. 1979; 39(5): 233-7[PubMed]
  • 26. Holder JL Jr, Wilfong AA. Zonisamide in the treatment of epilepsy. Expert Opin Pharmacother. 2011; 12(16): 2573-81[DOI][PubMed]
  • 27. Mula M, Trimble MR. Antiepileptic drug-induced cognitive adverse effects: potential mechanisms and contributing factors. CNS Drugs. 2009; 23(2): 121-37[DOI][PubMed]
  • 28. Onuma T. [Cognitive dysfunction and antiepileptic drugs]. Brain Nerve. 2011; 63(4): 379-83[PubMed]
  • 29. Semah F, Thomas P, Coulbaut S, Derambure P. Early add-on treatment vs alternative monotherapy in patients with partial epilepsy. Epileptic Disord. 2014; [DOI][PubMed]
  • 30. Fröscher W, Rösche J. Fortschr Neurol Psychiatr. Combination Ther epilepsy. 2013; 81(1): 9-20
  • 31. Witt J, Elger CE, Helmstaedter C. Which drug-induced side effects would be tolerated in the prospect of seizure control? Epilepsy Behav. 2013; 29(1): 141-3[DOI]
  • 32. Poduri A, Sheidley BR, Shostak S, Ottman R. Genetic testing in the epilepsies—developments and dilemmas. Nat Rev Neurol. 2014; 10(5): 293-9[DOI]
  • 33. French JA, Gazzola DM. Antiepileptic drug treatment: new drugs and new strategies. Continuum (Minneap Minn). 2013; 19(3 Epilepsy): 643-55[DOI][PubMed]
  • 34. Yi Y, Lee JH, Suh ES. Toxic epidermal necrolysis induced by lamotrigine treatment in a child. Korean J Pedi. 2014; 57(3): 153[DOI]
  • 35. Sarangi SC, Tripathi M, Kakkar AK, Gupta YK. Effect of antiepileptic therapy on trace elements status in Indian population in a tertiary care hospital from northern India: A cross sectional study. Epilepsy Res. 2014; 108(5): 917-27[DOI][PubMed]
  • 36. Li M, Tan J, Yang X, Su L, Xie J, Liang B, et al. The ABCB1-C3435T polymorphism likely acts as a risk factor for resistance to antiepileptic drugs. Epilepsy Res. 2014; [DOI][PubMed]
  • 37. Satishchandra P, Santhosh N, Sinha S. Epilepsy: Indian perspective. Ann Indian Acad Neurol. 2014; 17(5): 3[DOI]
  • 38. Nanau RM, Neuman MG. Adverse drug reactions induced by valproic acid. Clin Biochem. 2013; 46(15): 1323-38[DOI][PubMed]
  • 39. Pegg EJ, Zaman F. Sodium valproate-related hyperammonaemic encephalopathy. Case Rep. 2014; 2014[DOI]
  • 40. Anwar MJ, Radhakrishna KV, Vohora D. Phenytoin and sodium valproate but not levetiracetam induce bone alterations in female mice. Can J Physiol Pharmacol. 2014; [DOI][PubMed]
  • 41. Shingade PU, Wankhede V, Kataria PS, Sonone N. Rare case of phenytoin induced acute generalized exanthematous pustulosis with cerebellar syndrome. Indian J Dermatol. 2014; 59(2): 210[DOI][PubMed]
  • 42. Błaszczyk B, Szpringer M, Czuczwar SJ, Lasoń W. Single centre 20 year survey of antiepileptic drug-induced hypersensitivity reactions. Pharmacoll Rep. 2013; 65(2): 399-409[DOI]
  • 43. Bourgeois BF. Initiating antiepileptic drug treatment and characteristics of drugs. Handb Clin Neurol. 2013; 111: 719-25[DOI][PubMed]
  • 44. Wilkinson GR. Drug metabolism and variability among patients in drug response. N Engl J Med. 2005; 352(21): 2211-21[DOI][PubMed]
  • 45. Slaughter RL, Edwards DJ. Recent advances: the cytochrome P450 enzymes. Ann Pharmacother. 1995; 29(6): 619-24[PubMed]
  • 46. Weinshilboum R. Inheritance and drug response. N Engl J Med. 2003; 348(6): 529-37[DOI][PubMed]
  • 47. Phillips KA, Veenstra DL, Oren E, Lee JK, Sadee W. Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review. JAMA. 2001; 286(18): 2270-9[PubMed]
  • 48. Bradford LD. CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics. 2002; 3(2): 229-43[DOI][PubMed]
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