Archives of Neuroscience

Published by: Kowsar

Expressional Analysis of Inwardly Rectifying Kir4.1 Channels in Groggy Rats, a Rat Model of Absence Seizures

Yuya Harada 1 , Yuki Nagao 1 , Takahiro Mukai 1 , Saki Shimizu 1 , Kentaro Tokudome 1 , Naofumi Kunisawa 1 , Tadao Serikawa 1 , 2 , Masashi Sasa 3 and Yukihiro Ohno 1 , *
Authors Information
1 Laboratory of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
2 Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan
3 Nagisa Clinic, Hirakata, Osaka, Japan
Article information
  • Archives of Neuroscience: October 01, 2014, 1 (3); e18651
  • Published Online: October 1, 2014
  • Article Type: Research Article
  • Received: December 1, 2013
  • Revised: December 3, 2013
  • Accepted: December 5, 2013
  • DOI: 10.5812/archneurosci.18651

To Cite: Harada Y, Nagao Y, Mukai T, Shimizu S, Tokudome K, et al. Expressional Analysis of Inwardly Rectifying Kir4.1 Channels in Groggy Rats, a Rat Model of Absence Seizures, Arch Neurosci. 2014 ; 1(3):e18651. doi: 10.5812/archneurosci.18651.

Abstract
Copyright © 2014, Tehran University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Butt AM, Kalsi A. Inwardly rectifying potassium channels (Kir) in central nervous system glia: a special role for Kir4.1 in glial functions. J Cell Mol Med. 2006; 10(1): 33-44[PubMed]
  • 2. Furutani K, Ohno Y, Inanobe A, Hibino H, Kurachi Y. Mutational and in silico analyses for antidepressant block of astroglial inward-rectifier Kir4.1 channel. Mol Pharmacol. 2009; 75(6): 1287-95[DOI][PubMed]
  • 3. Kofuji P, Newman EA. Potassium buffering in the central nervous system. Neuroscience. 2004; 129(4): 1045-56[DOI][PubMed]
  • 4. Ohno Y, Hibino H, Lossin C, Inanobe A, Kurachi Y. Inhibition of astroglial Kir4.1 channels by selective serotonin reuptake inhibitors. Brain Res. 2007; 1178: 44-51[DOI][PubMed]
  • 5. Simard M, Nedergaard M. The neurobiology of glia in the context of water and ion homeostasis. Neuroscience. 2004; 129(4): 877-96[DOI][PubMed]
  • 6. Su S, Ohno Y, Lossin C, Hibino H, Inanobe A, Kurachi Y. Inhibition of astroglial inwardly rectifying Kir4.1 channels by a tricyclic antidepressant, nortriptyline. J Pharmacol Exp Ther. 2007; 320(2): 573-80[DOI][PubMed]
  • 7. Walz W. Role of astrocytes in the clearance of excess extracellular potassium. Neurochem Int. 2000; 36(4-5): 291-300[PubMed]
  • 8. Amiry-Moghaddam M, Ottersen OP. The molecular basis of water transport in the brain. Nat Rev Neurosci. 2003; 4(12): 991-1001[DOI][PubMed]
  • 9. Djukic B, Casper KB, Philpot BD, Chin LS, McCarthy KD. Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation. J Neurosci. 2007; 27(42): 11354-65[DOI][PubMed]
  • 10. Kucheryavykh YV, Kucheryavykh LY, Nichols CG, Maldonado HM, Baksi K, Reichenbach A, et al. Downregulation of Kir4.1 inward rectifying potassium channel subunits by RNAi impairs potassium transfer and glutamate uptake by cultured cortical astrocytes. Glia. 2007; 55(3): 274-81[DOI][PubMed]
  • 11. Nagelhus EA, Horio Y, Inanobe A, Fujita A, Haug FM, Nielsen S, et al. Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Muller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains. Glia. 1999; 26(1): 47-54[PubMed]
  • 12. Puwarawuttipanit W, Bragg AD, Frydenlund DS, Mylonakou MN, Nagelhus EA, Peters MF, et al. Differential effect of alpha-syntrophin knockout on aquaporin-4 and Kir4.1 expression in retinal macroglial cells in mice. Neuroscience. 2006; 137(1): 165-75[DOI][PubMed]
  • 13. Bockenhauer D, Feather S, Stanescu HC, Bandulik S, Zdebik AA, Reichold M, et al. Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations. N Engl J Med. 2009; 360(19): 1960-70[DOI][PubMed]
  • 14. Scholl UI, Choi M, Liu T, Ramaekers VT, Hausler MG, Grimmer J, et al. Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME syndrome) caused by mutations in KCNJ10. Proc Natl Acad Sci U S A. 2009; 106(14): 5842-7[DOI][PubMed]
  • 15. Reichold M, Zdebik AA, Lieberer E, Rapedius M, Schmidt K, Bandulik S, et al. KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function. Proc Natl Acad Sci U S A. 2010; 107(32): 14490-5[DOI][PubMed]
  • 16. Sala-Rabanal M, Kucheryavykh LY, Skatchkov SN, Eaton MJ, Nichols CG. Molecular mechanisms of EAST/SeSAME syndrome mutations in Kir4.1 (KCNJ10). J Biol Chem. 2010; 285(46): 36040-8[DOI][PubMed]
  • 17. Tang X, Hang D, Sand A, Kofuji P. Variable loss of Kir4.1 channel function in SeSAME syndrome mutations. Biochem Biophys Res Commun. 2010; 399(4): 537-41[DOI][PubMed]
  • 18. Harada Y, Nagao Y, Shimizu S, Serikawa T, Terada R, Fujimoto M, et al. Expressional analysis of inwardly rectifying Kir4.1 channels in Noda epileptic rat (NER). Brain Res. 2013; 1517: 141-9[DOI][PubMed]
  • 19. Nagao Y, Harada Y, Mukai T, Shimizu S, Okuda A, Fujimoto M, et al. Expressional analysis of the astrocytic Kir4.1 channel in a pilocarpine-induced temporal lobe epilepsy model. Front Cell Neurosci. 2013; 7: 104[DOI][PubMed]
  • 20. Das A, Wallace GCt, Holmes C, McDowell ML, Smith JA, Marshall JD, et al. Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptors. Neuroscience. 2012; 220: 237-46[DOI][PubMed]
  • 21. Heuser K, Eid T, Lauritzen F, Thoren AE, Vindedal GF, Tauboll E, et al. Loss of perivascular Kir4.1 potassium channels in the sclerotic hippocampus of patients with mesial temporal lobe epilepsy. J Neuropathol Exp Neurol. 2012; 71(9): 814-25[DOI][PubMed]
  • 22. Steinhauser C, Seifert G, Bedner P. Astrocyte dysfunction in temporal lobe epilepsy: K+ channels and gap junction coupling. Glia. 2012; 60(8): 1192-202[DOI][PubMed]
  • 23. Ohno Y, Sofue N, Imaoku T, Morishita E, Kumafuji K, Sasa M, et al. Serotonergic modulation of absence-like seizures in groggy rats: a novel rat model of absence epilepsy. J Pharmacol Sci. 2010; 114(1): 99-105[PubMed]
  • 24. Tokuda S, Kuramoto T, Tanaka K, Kaneko S, Takeuchi IK, Sasa M, et al. The ataxic groggy rat has a missense mutation in the P/Q-type voltage-gated Ca2+ channel alpha1A subunit gene and exhibits absence seizures. Brain Res. 2007; 1133(1): 168-77[DOI][PubMed]
  • 25. Tokuda S, Sofue N, Ohno Y, Sasa M, Serikawa T. Inhibitory effects of levetiracetam on absence seizures in a novel absence-like epilepsy animal model, Groggy rat. Brain Res. 2010; 1359: 298-303[DOI][PubMed]
  • 26. Howe MW, Feig SL, Osting SM, Haberly LB. Cellular and subcellular localization of Kir2.1 subunits in neurons and glia in piriform cortex with implications for K+ spatial buffering. J Comp Neurol. 2008; 506(5): 877-93[DOI][PubMed]
  • 27. Kang SJ, Cho SH, Park K, Yi J, Yoo SJ, Shin KS. Expression of Kir2.1 channels in astrocytes under pathophysiological conditions. Mol Cells. 2008; 25(1): 124-30[PubMed]
  • 28. Ohno Y, Ishihara S, Mashimo T, Sofue N, Shimizu S, Imaoku T, et al. Scn1a missense mutation causes limbic hyperexcitability and vulnerability to experimental febrile seizures. Neurobiol Dis. 2011; 41(2): 261-9[DOI][PubMed]
  • 29. Connors NC, Adams ME, Froehner SC, Kofuji P. The potassium channel Kir4.1 associates with the dystrophin-glycoprotein complex via alpha-syntrophin in glia. J Biol Chem. 2004; 279(27): 28387-92[DOI][PubMed]
  • 30. Seifert G, Huttmann K, Binder DK, Hartmann C, Wyczynski A, Neusch C, et al. Analysis of astroglial K+ channel expression in the developing hippocampus reveals a predominant role of the Kir4.1 subunit. J Neurosci. 2009; 29(23): 7474-88[DOI][PubMed]
  • 31. Takeuchi IK, Takeuchi YK. Neuronal degeneration in the striatum of the groggy rat: a new mutant with a movement disorder. Experientia. 1991; 47(11-12): 1215-8[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments