Archives of Neuroscience

Published by: Kowsar

Single Dose Antibiotic Prophylaxis in Lumbar Stenosis or Disc Surgery: A Review of 117 Cases

Zohreh Habibi 1 , 2 , * , Zaker saedinejad 3 and Owrang Eilami 3
Authors Information
1 Department of Neurosurgery, Children's Hospital Medical Center, Tehran University of Medical Sciences, Tehran, IR Iran
2 Brain and Spinal Cord Injury Research Center, Tehran, IR Iran
3 Department of Infectious Diseases, Yasuj University of Medical Sciences, Yasuj, IR Iran
Article information
  • Archives of Neuroscience: October 01, 2014, 1 (3); e15055
  • Published Online: October 1, 2014
  • Article Type: Research Article
  • Received: September 26, 2013
  • Revised: October 19, 2013
  • Accepted: November 2, 2013
  • DOI: 10.5812/archneurosci.15055

To Cite: Habibi Z, saedinejad Z, Eilami O. Single Dose Antibiotic Prophylaxis in Lumbar Stenosis or Disc Surgery: A Review of 117 Cases, Arch Neurosci. 2014 ; 1(3):e15055. doi: 10.5812/archneurosci.15055.

Copyright © 2014, Tehran University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Yamamoto M, Jimbo M, Ide M, Tanaka N, Umebara Y, Hagiwara S. Perioperative antimicrobial prophylaxis in neurosurgery: clinical trial of systemic flomoxef administration and saline containing gentamicin for irrigation. Neurol Med Chir (Tokyo). 1996; 36(6): 370-6[PubMed]
  • 2. Hellbusch LC, Helzer-Julin M, Doran SE, Leibrock LG, Long DJ, Puccioni MJ, et al. Single-dose vs multiple-dose antibiotic prophylaxis in instrumented lumbar fusion--a prospective study. Surg Neurol. 2008; 70(6): 622-7[DOI][PubMed]
  • 3. Askarian M, Reza Moravveji A, Assadian O. Prescription of prophylactic antibiotics for neurosurgical procedures in teaching hospitals in Iran. Am J Infect Control. 2007; 35(4): 260-2[DOI][PubMed]
  • 4. Mastronardi L, Tatta C. Intraoperative antibiotic prophylaxis in clean spinal surgery: a retrospective analysis in a consecutive series of 973 cases. Surg Neurol. 2004; 61(2): 129-35[PubMed]
  • 5. El-Gindi S, Aref S, Salama M, Andrew J. Infection of intervertebral discs after operation. J Bone Joint Surg Br. 1976; 58(1): 114-6[PubMed]
  • 6. Kanayama M, Hashimoto T, Shigenobu K, Oha F, Togawa D. Effective prevention of surgical site infection using a Centers for Disease Control and Prevention guideline-based antimicrobial prophylaxis in lumbar spine surgery. J Neurosurg Spine. 2007; 6(4): 327-9[DOI][PubMed]
  • 7. ASHP Therapeutic Guidelines on Antimicrobial Prophylaxis in Surgery. American Society of Health-System Pharmacists. Am J Health Syst Pharm. 1999; 56(18): 1839-88[PubMed]
  • 8. Dobzyniak MA, Fischgrund JS, Hankins S, Herkowitz HN. Single versus multiple dose antibiotic prophylaxis in lumbar disc surgery. Spine (Phila Pa 1976). 2003; 28(21)-5[DOI][PubMed]
  • 9. Horwitz NH, Curtin JA. Prophylactic antibiotics and wound infections following laminectomy for lumber disc herniation. J Neurosurg. 1975; 43(6): 727-31[DOI][PubMed]
  • 10. Zhu XL, Wong WK, Yeung WM, Mo P, Tsang CS, Pang KH, et al. A randomized, double-blind comparison of ampicillin/sulbactam and ceftriaxone in the prevention of surgical-site infections after neurosurgery. Clin Ther. 2001; 23(8): 1281-91[PubMed]
  • 11. Classen DC, Evans RS, Pestotnik SL, Horn SD, Menlove RL, Burke JP. The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection. N Engl J Med. 1992; 326(5): 281-6[DOI][PubMed]
  • 12. Kanayama M, Oha F, Togawa D, Shigenobu K, Hashimoto T. Is closed-suction drainage necessary for single-level lumbar decompression?: review of 560 cases. Clin Orthop Relat Res. 2010; 468(10): 2690-4[DOI][PubMed]
  • 13. Khan IU, Janjua MB, Hasan S, Shah S. Surgical site infection in lumbar surgeries, pre and postoperative antibiotics and length of stay: a case study. J Ayub Med Coll Abbottabad. 2009; 21(3): 135-8[PubMed]
  • 14. Mahdaviazad H, Masoompour SM, Askarian M. Iranian surgeons' compliance with the American Society of Health-System Pharmacists guidelines: antibiotic prophylaxis in private versus teaching hospitals in Shiraz, Iran. J Infect Public Health. 2011; 4(5-6): 253-9[DOI][PubMed]
  • 15. Ohtori S, Inoue G, Koshi T, Yamashita M, Yamauchi K, Suzuki M, et al. Long-term intravenous administration of antibiotics for lumbar spinal surgery prolongs the duration of hospital stay and time to normalize body temperature after surgery. Spine (Phila Pa 1976). 2008; 33(26): 2935-7[DOI][PubMed]
  • 16. Housden PL, Sullivan MF. Do augmentin or cefuroxime reach effective levels in lumbar vertebral discs when used prophylactically for discectomy? A preliminary report. Eur Spine J. 1993; 2(3): 145-8[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments