Archives of Neuroscience

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Alzheimers’ Disease and Epilepsy: A Literature Review

Francesco Raudino 1 , *
Author Information
1 Department of Neurology Valduce Hospital, Como, Italy
Article information
  • Archives of Neuroscience: April 2017, 4 (2); e39578
  • Published Online: October 18, 2016
  • Article Type: Review Article
  • Received: May 30, 2016
  • Revised: August 3, 2016
  • Accepted: September 25, 2016
  • DOI: 10.5812/archneurosci.39578

To Cite: Raudino F. Alzheimers’ Disease and Epilepsy: A Literature Review, Arch Neurosci. 2017 ; 4(2):e39578. doi: 10.5812/archneurosci.39578.

Abstract
Copyright © 2016, Tehran University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Discussion
Footnote
References
  • 1. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984; 34(7): 939-44[PubMed]
  • 2. Alzheimer A, Forstl H, Levy R. On certain peculiar diseases of old age. Hist Psychiatry. 1991; 2(5 Pt 1): 71-101[PubMed]
  • 3. Sjogren T, Sjogren H, Lindgren AG. Morbus Alzheimer and morbus Pick; a genetic, clinical and patho-anatomical study. Acta Psychiatr Neurol Scand Suppl. 1952; 82: 1-152[PubMed]
  • 4. Letemendia F, Pampiglione G. Clinical and electroencephalographic observations in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 1958; 21(3): 167-72[PubMed]
  • 5. Hauser WA, Morris ML, Heston LL, Anderson VE. Seizures and myoclonus in patients with Alzheimer's disease. Neurology. 1986; 36(9): 1226-30[PubMed]
  • 6. Sulkava R. Alzheimer's disease and senile dementia of Alzheimer type. A comparative study. Acta Neurol Scand. 1982; 65(6): 636-50[PubMed]
  • 7. Risse SC, Lampe TH, Bird TD, Nochlin D, Sumi SM, Keenan T, et al. Myoclonus, seizures, and paratonia in Alzheimer disease. Alzheimer Dis Assoc Disord. 1990; 4(4): 217-25[PubMed]
  • 8. Romanelli MF, Morris JC, Ashkin K, Coben LA. Advanced Alzheimer's disease is a risk factor for late-onset seizures. Arch Neurol. 1990; 47(8): 847-50[PubMed]
  • 9. Forstl H, Burns A, Levy R, Cairns N, Luthert P, Lantos P. Neurologic signs in Alzheimer's disease. Results of a prospective clinical and neuropathologic study. Arch Neurol. 1992; 49(10): 1038-42[PubMed]
  • 10. Mendez MF, Catanzaro P, Doss RC, A. Rguello R , Frey W2. Seizures in Alzheimer's disease: clinicopathologic study. J Geriatr Psychiatry Neurol. 1994; 7(4): 230-3[PubMed]
  • 11. Volicer L, Smith S, Volicer BJ. Effect of seizures on progression of dementia of the Alzheimer type. Dementia. 1995; 6(5): 258-63[PubMed]
  • 12. Amatniek JC, Hauser WA, DelCastillo-Castaneda C, Jacobs DM, Marder K, Bell K, et al. Incidence and predictors of seizures in patients with Alzheimer's disease. Epilepsia. 2006; 47(5): 867-72[DOI][PubMed]
  • 13. Lozsadi DA, Larner AJ. Prevalence and causes of seizures at the time of diagnosis of probable Alzheimer's disease. Dement Geriatr Cogn Disord. 2006; 22(2): 121-4[DOI][PubMed]
  • 14. Scarmeas N, Honig LS, Choi H, Cantero J, Brandt J, Blacker D, et al. Seizures in Alzheimer disease: who, when, and how common? Arch Neurol. 2009; 66(8): 992-7[DOI][PubMed]
  • 15. Rao SC, Dove G, Cascino GD, Petersen RC. Recurrent seizures in patients with dementia: frequency, seizure types, and treatment outcome. Epilepsy Behav. 2009; 14(1): 118-20[DOI][PubMed]
  • 16. Bernardi S, Scaldaferri N, Vanacore N, Trebbastoni A, Francia A, D'Amico A, et al. Seizures in Alzheimer's disease: a retrospective study of a cohort of outpatients. Epileptic Disord. 2010; 12(1): 16-21[DOI][PubMed]
  • 17. Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, et al. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol. 2013; 70(9): 1158-66[DOI][PubMed]
  • 18. Imfeld P, Bodmer M, Schuerch M, Jick SS, Meier CR. Seizures in patients with Alzheimer's disease or vascular dementia: a population-based nested case-control analysis. Epilepsia. 2013; 54(4): 700-7[DOI][PubMed]
  • 19. Picco A, Archetti S, Ferrara M, Arnaldi D, Piccini A, Serrati C, et al. Seizures can precede cognitive symptoms in late-onset Alzheimer's disease. J Alzheimers Dis. 2011; 27(4): 737-42[DOI][PubMed]
  • 20. Cretin B, Blanc F, Gaultier C, Sellal F. Epileptic Amnesic Syndrome revealing Alzheimer's disease. Epilepsy Res. 2012; 102(3): 206-9[DOI][PubMed]
  • 21. Irizarry MC, Jin S, He F, Emond JA, Raman R, Thomas RG, et al. Incidence of new-onset seizures in mild to moderate Alzheimer disease. Arch Neurol. 2012; 69(3): 368-72[DOI][PubMed]
  • 22. Sherzai D, Losey T, Vega S, Sherzai A. Seizures and dementia in the elderly: Nationwide Inpatient Sample 1999-2008. Epilepsy Behav. 2014; 36: 53-6[DOI][PubMed]
  • 23. Cheng CH, Liu CJ, Ou SM, Yeh CM, Chen TJ, Lin YY, et al. Incidence and risk of seizures in Alzheimer's disease: A nationwide population-based cohort study. Epilepsy Res. 2015; 115: 63-6[DOI][PubMed]
  • 24. Zarea A, Charbonnier C, Rovelet-Lecrux A, Nicolas G, Rousseau S, Borden A, et al. Seizures in dominantly inherited Alzheimer disease. Neurology. 2016; 87(9): 912-9[DOI][PubMed]
  • 25. Liedorp M, Stam CJ, van der Flier WM, Pijnenburg YA, Scheltens P. Prevalence and clinical significance of epileptiform EEG discharges in a large memory clinic cohort. Dement Geriatr Cogn Disord. 2010; 29(5): 432-7[DOI][PubMed]
  • 26. Hesdorffer DC, Hauser WA, Annegers JF, Kokmen E, Rocca WA. Dementia and adult-onset unprovoked seizures. Neurology. 1996; 46(3): 727-30[PubMed]
  • 27. Yarchoan M, Xie SX, Kling MA, Toledo JB, Wolk DA, Lee EB, et al. Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias. Brain. 2012; 135: 3749-56[DOI][PubMed]
  • 28. Wollenweber FA, Buerger K, Mueller C, Ertl-Wagner B, Malik R, Dichgans M, et al. Prevalence of cortical superficial siderosis in patients with cognitive impairment. J Neurol. 2014; 261(2): 277-82[DOI][PubMed]
  • 29. Zonneveld HI, Goos JD, Wattjes MP, Prins ND, Scheltens P, van der Flier WM, et al. Prevalence of cortical superficial siderosis in a memory clinic population. Neurology. 2014; 82(8): 698-704[DOI][PubMed]
  • 30. Vernooij MW, Ikram MA, Hofman A, Krestin GP, Breteler MM, van der Lugt A. Superficial siderosis in the general population. Neurology. 2009; 73(3): 202-5[DOI][PubMed]
  • 31. Ponomareva NV, Selesneva ND, Jarikov GA. EEG alterations in subjects at high familial risk for Alzheimer's disease. Neuropsychobiology. 2003; 48(3): 152-9[PubMed]
  • 32. Ponomareva NV, Korovaitseva GI, Rogaev EI. EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of Alzheimer disease. Neurobiol Aging. 2008; 29(6): 819-27[DOI][PubMed]
  • 33. Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Helkala EL, Hartikainen P, et al. Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism. Neurology. 1996; 46(2): 413-9[PubMed]
  • 34. Sporis D, Sertic J, Henigsberg N, Mahovic D, Bogdanovic N, Babic T. Association of refractory complex partial seizures with a polymorphism of ApoE genotype. J Cell Mol Med. 2005; 9(3): 698-703[PubMed]
  • 35. Babic T, Zurak N. Convulsions induced by donepezil. J Neurol Neurosurg Psychiatry. 1999; 66(3): 410[PubMed]
  • 36. Peltz G, Pacific DM, Noviasky JA, Shatla A, Mehalic T. Seizures associated with memantine use. Am J Health Syst Pharm. 2005; 62(4): 420-1[PubMed]
  • 37. Cardamone L, Salzberg MR, Koe AS, Ozturk E, O'Brien TJ, Jones NC. Chronic antidepressant treatment accelerates kindling epileptogenesis in rats. Neurobiol Dis. 2014; 63: 194-200[DOI][PubMed]
  • 38. Eyal S, Rasaby S, Ekstein D. Concomitant therapy in people with epilepsy: potential drug-drug interactions and patient awareness. Epilepsy Behav. 2014; 31: 369-76[DOI][PubMed]
  • 39. Fisher RS, Bortz JJ, Blum DE, Duncan B, Burke H. A pilot study of donepezil for memory problems in epilepsy. Epilepsy Behav. 2001; 2(4): 330-4[DOI][PubMed]
  • 40. Hamberger MJ, Palmese CA, Scarmeas N, Weintraub D, Choi H, Hirsch LJ. A randomized, double-blind, placebo-controlled trial of donepezil to improve memory in epilepsy. Epilepsia. 2007; 48(7): 1283-91[DOI][PubMed]
  • 41. Bell JS, Lonnroos E, Koivisto AM, Lavikainen P, Laitinen ML, Soininen H, et al. Use of antiepileptic drugs among community-dwelling persons with Alzheimer's disease in Finland. J Alzheimers Dis. 2011; 26(2): 231-7[DOI][PubMed]
  • 42. Fleisher AS, Truran D, Mai JT, Langbaum JB, Aisen PS, Cummings JL, et al. Chronic divalproex sodium use and brain atrophy in Alzheimer disease. Neurology. 2011; 77(13): 1263-71[DOI][PubMed]
  • 43. Belcastro V, Costa C, Galletti F, Pisani F, Calabresi P, Parnetti L. Levetiracetam monotherapy in Alzheimer patients with late-onset seizures: a prospective observational study. Eur J Neurol. 2007; 14(10): 1176-8[DOI][PubMed]
  • 44. Cumbo E, Ligori LD. Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer's disease. Epilepsy Behav. 2010; 17(4): 461-6[DOI][PubMed]
  • 45. Samson WN, van Duijn CM, Hop WC, Hofman A. Clinical features and mortality in patients with early-onset Alzheimer's disease. Eur Neurol. 1996; 36(2): 103-6[PubMed]
  • 46. Borroni B, Pilotto A, Bonvicini C, Archetti S, Alberici A, Lupi A, et al. Atypical presentation of a novel Presenilin 1 R377W mutation: sporadic, late-onset Alzheimer disease with epilepsy and frontotemporal atrophy. Neurol Sci. 2012; 33(2): 375-8[DOI][PubMed]
  • 47. Helmstaedter C, Kurthen M. Memory and epilepsy: characteristics, course, and influence of drugs and surgery. Curr Opin Neurol. 2001; 14(2): 211-6[PubMed]
  • 48. Hoppe C, Elger CE. Depression in epilepsy: a critical review from a clinical perspective. Nat Rev Neurol. 2011; 7(8): 462-72[DOI][PubMed]
  • 49. Thom M, Liu JY, Thompson P, Phadke R, Narkiewicz M, Martinian L, et al. Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study. Brain. 2011; 134: 2969-81[DOI][PubMed]
  • 50. Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, et al. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron. 2007; 55(5): 697-711[DOI][PubMed]
  • 51. Minkeviciene R, Rheims S, Dobszay MB, Zilberter M, Hartikainen J, Fulop L, et al. Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy. J Neurosci. 2009; 29(11): 3453-62[DOI][PubMed]
  • 52. Vogt DL, Thomas D, Galvan V, Bredesen DE, Lamb BT, Pimplikar SW. Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain. Neurobiol Aging. 2011; 32(9): 1725-9[DOI][PubMed]
  • 53. Yan XX, Cai Y, Shelton J, Deng SH, Luo XG, Oddo S, et al. Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3xTg-AD mice. PLoS One. 2012; 7(11): 48782[DOI][PubMed]
  • 54. Holmes GL, Lenck-Santini PP. Role of interictal epileptiform abnormalities in cognitive impairment. Epilepsy Behav. 2006; 8(3): 504-15[DOI][PubMed]
  • 55. Kleen JK, Scott RC, Holmes GL, Lenck-Santini PP. Hippocampal interictal spikes disrupt cognition in rats. Ann Neurol. 2010; 67(2): 250-7[DOI][PubMed]
  • 56. Corbett BF, Leiser SC, Ling HP, Nagy R, Breysse N, Zhang X, et al. Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease. J Neurosci. 2013; 33(16): 7020-6[DOI][PubMed]
  • 57. Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, et al. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science. 2007; 316(5825): 750-4[DOI][PubMed]
  • 58. Zarow C, Sitzer TE, Chui HC. Understanding hippocampal sclerosis in the elderly: epidemiology, characterization, and diagnostic issues. Curr Neurol Neurosci Rep. 2008; 8(5): 363-70[PubMed]
  • 59. Kordower JH, Chu Y, Stebbins GT, DeKosky ST, Cochran EJ, Bennett D, et al. Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment. Ann Neurol. 2001; 49(2): 202-13[PubMed]
  • 60. Du F, Whetsell WJ, Abou-Khalil B, Blumenkopf B, Lothman EW, Schwarcz R. Preferential neuronal loss in layer III of the entorhinal cortex in patients with temporal lobe epilepsy. Epilepsy Res. 1993; 16(3): 223-33[PubMed]
  • 61. Scharfman HE. "Untangling" Alzheimer's disease and epilepsy. Epilepsy Curr. 2012; 12(5): 178-83[DOI][PubMed]
  • 62. Tariot PN, Schneider LS, Cummings J, Thomas RG, Raman R, Jakimovich LJ, et al. Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease. Arch Gen Psychiatry. 2011; 68(8): 853-61[DOI][PubMed]
  • 63. Koh MT, Haberman RP, Foti S, McCown TJ, Gallagher M. Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment. Neuropsychopharmacology. 2010; 35(4): 1016-25[DOI][PubMed]
  • 64. Koh MT, Rosenzweig-Lipson S, Gallagher M. Selective GABA(A) alpha5 positive allosteric modulators improve cognitive function in aged rats with memory impairment. Neuropharmacology. 2013; 64: 145-52[DOI][PubMed]
  • 65. Devi L, Ohno M. Effects of levetiracetam, an antiepileptic drug, on memory impairments associated with aging and Alzheimer's disease in mice. Neurobiol Learn Mem. 2013; 102: 7-11[DOI][PubMed]
  • 66. Raudino F. Non-cognitive symptoms and related conditions in the Alzheimer's disease: a literature review. Neurol Sci. 2013; 34(8): 1275-82[DOI][PubMed]
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