Archives of Neuroscience

Published by: Kowsar

Effect of Intrahippocampal CA3 Injection of Spexin on Passive Avoidance Learning and Memory in Normal and Castrated Rats

Mahnaz Taherianfard 1 , * and Diaco Shahmoradi 1
Authors Information
1 Devision of Physiology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Article information
  • Archives of Neuroscience: April 2018, 5 (2); e14461
  • Published Online: April 24, 2018
  • Article Type: Research Article
  • Received: June 2, 2017
  • Revised: September 18, 2017
  • Accepted: January 24, 2018
  • DOI: 10.5812/archneurosci.14461

To Cite: Taherianfard M, Shahmoradi D. Effect of Intrahippocampal CA3 Injection of Spexin on Passive Avoidance Learning and Memory in Normal and Castrated Rats, Arch Neurosci. 2018 ; 5(2):e14461. doi: 10.5812/archneurosci.14461.

Abstract
Copyright © 2018, Archives of Neuroscience. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
Acknowledgements
Footnote
References
  • 1. Meilandt WJ, Barea-Rodriguez E, Harvey SA, Martinez JJ. Role of hippocampal CA3 mu-opioid receptors in spatial learning and memory. J Neurosci. 2004;24(12):2953-62. doi: 10.1523/JNEUROSCI.5569-03.2004. [PubMed: 15044534].
  • 2. Naghdi N, Asadollahi A. Genomic and nongenomic effects of intrahippocampal microinjection of testosterone on long-term memory in male adult rats. Behav Brain Res. 2004;153(1):1-6. doi: 10.1016/j.bbr.2003.10.027. [PubMed: 15219700].
  • 3. Harooni HE, Naghdi N, Sepehri H, Rohani AH. Intra hippocampal injection of testosterone impaired acquisition, consolidation and retrieval of inhibitory avoidance learning and memory in adult male rats. Behav Brain Res. 2008;188(1):71-7. doi: 10.1016/j.bbr.2007.10.017. [PubMed: 18054400].
  • 4. Sandstrom NJ, Kim JH, Wasserman MA. Testosterone modulates performance on a spatial working memory task in male rats. Horm Behav. 2006;50(1):18-26. doi: 10.1016/j.yhbeh.2005.09.008. [PubMed: 16263125].
  • 5. Mukai H, Kimoto T, Hojo Y, Kawato S, Murakami G, Higo S, et al. Modulation of synaptic plasticity by brain estrogen in the hippocampus. Biochim Biophys Acta. 2010;1800(10):1030-44. doi: 10.1016/j.bbagen.2009.11.002. [PubMed: 19909788].
  • 6. Naftolin F. Brain aromatization of androgens. J Reprod Med. 1994;39(4):257-61. [PubMed: 8040841].
  • 7. Mirabeau O, Perlas E, Severini C, Audero E, Gascuel O, Possenti R, et al. Identification of novel peptide hormones in the human proteome by hidden Markov model screening. Genome Res. 2007;17(3):320-7. doi: 10.1101/gr.5755407. [PubMed: 17284679].
  • 8. Porzionato A, Rucinski M, Macchi V, Stecco C, Malendowicz LK, De Caro R. Spexin expression in normal rat tissues. J Histochem Cytochem. 2010;58(9):825-37. doi: 10.1369/jhc.2010.956300. [PubMed: 20530460].
  • 9. Yu Y, Zeng C, Shu S, Liu X, Li C. Similar effects of substance P on learning and memory function between hippocampus and striatal marginal division. Neural Regen Res. 2014;9(8):857-63. doi: 10.4103/1673-5374.131603. [PubMed: 25206901].
  • 10. Toll L, Khroyan TV, Sonmez K, Ozawa A, Lindberg I, McLaughlin JP, et al. Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception. FASEB J. 2012;26(2):947-54. doi: 10.1096/fj.11-192831. [PubMed: 22038051].
  • 11. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. 6th ed. Berlin: Elsevier Academic Press; 2004.
  • 12. Wolf OT, Preut R, Hellhammer DH, Kudielka BM, Schurmeyer TH, Kirschbaum C. Testosterone and cognition in elderly men: a single testosterone injection blocks the practice effect in verbal fluency, but has no effect on spatial or verbal memory. Biol Psychiatry. 2000;47(7):650-4. doi: 10.1016/S0006-3223(99)00145-6. [PubMed: 10745058].
  • 13. Maki PM, Ernst M, London ED, Mordecai KL, Perschler P, Durso SC, et al. Intramuscular testosterone treatment in elderly men: evidence of memory decline and altered brain function. J Clin Endocrinol Metab. 2007;92(11):4107-14. doi: 10.1210/jc.2006-1805. [PubMed: 17726086].
  • 14. Fedotova YO. Comparative characteristics of learning and behavior processes in conditions of elevated sex hormone levels. Neurosci Behav Physiol. 1999;29(5):605-7. doi: 10.1007/BF02461154. [PubMed: 10596798].
  • 15. Kim DK, Yun S, Son GH, Hwang JI, Park CR, Kim JI, et al. Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology. 2014;155(5):1864-73. doi: 10.1210/en.2013-2106. [PubMed: 24517231].
  • 16. Merchenthaler I, Lopez FJ, Negro-Vilar A. Anatomy and physiology of central galanin-containing pathways. Prog Neurobiol. 1993;40(6):711-69. doi: 10.1016/0301-0082(93)90012-H. [PubMed: 7683433].
  • 17. Li L, Yu L, Kong Q. Exogenous galanin attenuates spatial memory impairment and decreases hippocampal beta-amyloid levels in rat model of Alzheimer's disease. Int J Neurosci. 2013;123(11):759-65. doi: 10.3109/00207454.2013.800976. [PubMed: 23687905].
  • 18. Ogren SO, Kuteeva E, Elvander-Tottie E, Hokfelt T. Neuropeptides in learning and memory processes with focus on galanin. Eur J Pharmacol. 2010;626(1):9-17. doi: 10.1016/j.ejphar.2009.09.070. [PubMed: 19837050].
  • 19. Mennicken F, Hoffert C, Pelletier M, Ahmad S, O'Donnell D. Restricted distribution of galanin receptor 3 (GalR3) mRNA in the adult rat central nervous system. J Chem Neuroanat. 2002;24(4):257-68. doi: 10.1016/S0891-0618(02)00068-6. [PubMed: 12406501].
  • 20. Schott PA, Bjelke B, Ogren SO. Time-dependent effects of intrahippocampal galanin on spatial learning. Relationship to distribution and kinetics. Ann N Y Acad Sci. 1998;863:454-6. [PubMed: 9928198].
  • 21. Liu Y, Li S, Qi X, Zhou W, Liu X, Lin H, et al. A novel neuropeptide in suppressing luteinizing hormone release in goldfish, Carassius auratus. Mol Cell Endocrinol. 2013;374(1-2):65-72. doi: 10.1016/j.mce.2013.04.008. [PubMed: 23623870].
  • 22. Mirzaei SH, Taherianfard M, Tadjali M, Kohkaloyeh M. Castration and passive avoidance learning alter the distribution of N-Methyl D-Aspartate receptor. Am J Neurosci. 2013;4(1):39-45. doi: 10.3844/amjnsp.2013.39.45.
  • 23. Daniel JM, Winsauer PJ, Moerschbaecher JM. Castration in rats impairs performance during acquisition of a working memory task and exacerbates deficits in working memory produced by scopolamine and mecamylamine. Psychopharmacology (Berl). 2003;170(3):294-300. doi: 10.1007/s00213-003-1537-4. [PubMed: 12898124].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments