Archives of Neuroscience

Published by: Kowsar

Cerebellar Ataxia, Celiac Disease and Non-Celiac Gluten Sensitivity

Giovanni Casella 1 , * , Ignazio Santilli 2 , Camillo Di Bella 3 , Valentina Crisafulli 4 , Vincenzo Villanacci 4 , Vittorio Baldini 5 and Gabrio Bassotti 6
Authors Information
1 Medical Department, Desio Hospital, ASST Monza, Desio (Monza Brianza), Italy
2 MD, Chief Neurology Department, Desio Hospital, ASST Monza, Desio (Monza Brianza), Italy
3 MD, Pathology Department, Carate Brianza Hospital, ASST Vimercate, Carate Brianza (Monza Brianza), Italy
4 MD, Institute of Pathology, Spedali Civili Brescia, ASST Spedali Civili Brescia, Brescia, Italy
5 MD, Chief Medical Department, Desio Hospital, ASST Monza, Desio (Monza Brianza), Italy
6 Prof, Gastroenterology and Hepatology Section, Department of Medicine, University of Perugia Medical School, Italy
Article information
  • Archives of Neuroscience: April 2017, 4 (2); e44187
  • Published Online: April 23, 2017
  • Article Type: Review Article
  • Received: November 22, 2016
  • Accepted: January 18, 2017
  • DOI: 10.5812/archneurosci.44187

To Cite: Casella G, Santilli I, Di Bella C, Crisafulli V, Villanacci V, et al. Cerebellar Ataxia, Celiac Disease and Non-Celiac Gluten Sensitivity, Arch Neurosci. 2017 ; 4(2):e44187. doi: 10.5812/archneurosci.44187.

Abstract
Copyright © 2017, Tehran University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Prevalence
3. Clinical Manifestations
4. Diagnosis
5. Treatment
6. Cerebellar Ataxia in Non Celiac Gluten Sensitivity (NCGS)
7. Conclusions
References
  • 1. Fasano A. Celiac disease--how to handle a clinical chameleon. N Engl J Med. 2003; 348(25): 2568-70[DOI][PubMed]
  • 2. Hadjivassiliou M, Gibson A, Davies-Jones GA, Lobo AJ, Stephenson TJ, Milford-Ward A. Does cryptic gluten sensitivity play a part in neurological illness? Lancet. 1996; 347(8998): 369-71[PubMed]
  • 3. Bushara KO. Neurologic presentation of celiac disease. Gastroenterology. 2005; 128(4 Suppl 1)-7[PubMed]
  • 4. Briani C, Zara G, Alaedini A, Grassivaro F, Ruggero S, Toffanin E, et al. Neurological complications of celiac disease and autoimmune mechanisms: a prospective study. J Neuroimmunol. 2008; 195(1-2): 171-5[DOI][PubMed]
  • 5. Burk K, Bosch S, Muller CA, Melms A, Zuhlke C, Stern M, et al. Sporadic cerebellar ataxia associated with gluten sensitivity. Brain. 2001; 124: 1013-9[PubMed]
  • 6. Luostarinen L, Pirttila T, Collin P. Coeliac disease presenting with neurological disorders. Eur Neurol. 1999; 42(3): 132-5[PubMed]
  • 7. Hadjivassiliou M, Boscolo S, Tongiorgi E, Grunewald RA, Sharrack B, Sanders DS, et al. Cerebellar ataxia as a possible organ-specific autoimmune disease. Mov Disord. 2008; 23(10): 1370-7[DOI][PubMed]
  • 8. Hadjivassiliou M, Sanders DS, Grunewald RA, Woodroofe N, Boscolo S, Aeschlimann D. Gluten sensitivity: from gut to brain. Lancet Neurol. 2010; 9(3): 318-30[DOI][PubMed]
  • 9. Khwaja GA, Bohra V, Duggal A, Ghuge VV, Chaudhary N. Gluten Sensitivity - A Potentially Reversible Cause of Progressive Cerebellar Ataxia and Myoclonus - A Case Report. J Clin Diagn Res. 2015; 9(11)-8[DOI][PubMed]
  • 10. Hadjivassiliou M, Aeschlimann P, Strigun A, Sanders DS, Woodroofe N, Aeschlimann D. Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase. Ann Neurol. 2008; 64(3): 332-43[DOI][PubMed]
  • 11. Hadjivassiliou M. Ataxia Disorders 1 Clinical Neurological Series 3. 2014;
  • 12. Hadjivassiliou M, Sanders DS, Woodroofe N, Williamson C, Grunewald RA. Gluten ataxia. Cerebellum. 2008; 7(3): 494-8[DOI][PubMed]
  • 13. Hadjivassiliou M, Grunewald RA, Chattopadhyay AK, Davies-Jones GA, Gibson A, Jarratt JA, et al. Clinical, radiological, neurophysiological, and neuropathological characteristics of gluten ataxia. Lancet. 1998; 352(9140): 1582-5[PubMed]
  • 14. Ihara M, Makino F, Sawada H, Mezaki T, Mizutani K, Nakase H, et al. Gluten sensitivity in Japanese patients with adult-onset cerebellar ataxia. Intern Med. 2006; 45(3): 135-40[PubMed]
  • 15. Hadjivassiliou M, Rao DG, Grinewald RA, Aeschlimann DP, Sarrigiannis PG, Hoggard N, et al. Neurological Dysfunction in Coeliac Disease and Non-Coeliac Gluten Sensitivity. Am J Gastroenterol. 2016; 111(4): 561-7[DOI][PubMed]
  • 16. Hadjivassiliou M, Aeschlimann P, Sanders DS, Maki M, Kaukinen K, Grunewald RA, et al. Transglutaminase 6 antibodies in the diagnosis of gluten ataxia. Neurology. 2013; 80(19): 1740-5[DOI][PubMed]
  • 17. Hadjivassiliou M, Maki M, Sanders DS, Williamson CA, Grunewald RA, Woodroofe NM, et al. Autoantibody targeting of brain and intestinal transglutaminase in gluten ataxia. Neurology. 2006; 66(3): 373-7[DOI][PubMed]
  • 18. Wilkinson ID, Hadjivassiliou M, Dickson JM, Wallis L, Grunewald RA, Coley SC, et al. Cerebellar abnormalities on proton MR spectroscopy in gluten ataxia. J Neurol Neurosurg Psychiatry. 2005; 76(7): 1011-3[DOI][PubMed]
  • 19. Mauro A, Orsi L, Mortara P, Costa P, Schiffer D. Cerebellar syndrome in adult celiac disease with vitamin E deficiency. Acta Neurol Scand. 1991; 84(2): 167-70[PubMed]
  • 20. Jackson CE, Amato AA, Barohn RJ. Isolated vitamin E deficiency. Muscle Nerve. 1996; 19(9): 1161-5[DOI][PubMed]
  • 21. Shams PN, Waldman A, Plant GT. B Cell lymphoma of the brain stem masquerading as myasthenia. J Neurol Neurosurg Psychiatry. 2002; 72(2): 271-3[PubMed]
  • 22. Aziz I, Hadjivassiliou M, Sanders DS. The spectrum of noncoeliac gluten sensitivity. Nat Rev Gastroenterol Hepatol. 2015; 12(9): 516-26[DOI][PubMed]
  • 23. Volta U, Bardella MT, Calabro A, Troncone R, Corazza GR, Study Group for Non-Celiac Gluten S. An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity. BMC Med. 2014; 12: 85[DOI][PubMed]
  • 24. Hadjivassiliou M, Duker AP, Sanders DS. Gluten-related neurologic dysfunction. Handb Clin Neurol. 2014; 120: 607-19[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments